In men diagnosed with azoospermia (sperm count of zero in the semen) by the standard recommended laboratory procedure, a few sperm cells may be identified in the semen following additional centrifugation. When these very few sperm cells are found, the diagnosis is changed from azoospermia to cryptozoospermia. Dr. Parviz Kavoussi co-authored a research paper assessing whether using Cytospin centrifugation along with nuclear fast picoindigocarmine (NF-PIC) staining can detect sperm in semen samples which they labeled as azoospermic by standard laboratory technique. This study has shown effectiveness in doing so and possibly finding more men to truly be cryptozoospermic rather than azoospermic.
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