One of the long-standing challenges in men with testosterone deficiency has been treatment for this condition in a manner that does not suppress sperm production but also optimizes symptomatic response to treatment. Traditional testosterone replacement treatments, such as gels and intramuscular injections, significantly suppress sperm production. This has left limited treatment options for men wanting treatment for testosterone deficiency but also desiring to maintain fertility potential. The classic options for men in this situation have been off-label medications such as clomiphene citrate and hCG. However, many men do not get as robust of a symptomatic response on these medications as they do on direct testosterone replacement.
Dr. Kavoussi published a research study revealing that a possible exception to the rule is the intranasal testosterone replacement Natesto. His study showed that for men treated with clomiphene citrate for testosterone deficiency who did not get a robust symptom response, changing treatment to Natesto allowed them to improve their symptomatic response while maintaining sperm production. He was recently featured on Lifetime networks, the Balancing Act, to discuss how this treatment works. Dr. Kavoussi states, “This is quite an exciting breakthrough to be able to offer a form of direct testosterone replacement with optimal symptomatic response in a manner that can maintain sperm production. That being said, the data is young and early, so we still need to follow men’s fertility hormones and semen parameters on Natesto closely to confirm we are not doing any harm from a fertility standpoint.”
To watch this segment on the Balancing Act, click here