There is a great deal of controversy in the scientific research on whether Clomiphene Citrate, a commonly used medication to treat low testosterone in men who want to maintain fertility potential in a way that is not detrimental for sperm, actually improves semen parameters on not. Several studies have shown some improvement in some semen parameters, and other studies have shown no impact.
At the 2017 American Society for Reproductive Medicine annual expo and scientific meeting, Dr. Kavoussi’s research was presented on the topic of predictive factors that could potential be used to see which patient’s may respond to Clomiphene Citrate with an improvement in semen parameters. Ultimately, the data showed no significant difference in semen volume or sperm count, but an improvement in sperm motility. There were no predictive factors that could be identified in which men had this improvement.
Dr. Kavoussi states, “We believe further study is required, but the jury is still out. There is not enough solid evidence that Clomiphene Citrate improves semen parameters in subfertile men at this time. That being said, it continues to be an excellent treatment option for low testosterone for subfertile men and men wanting to maintain fertility potential.”